Importance of Ribonucleotide Reductase (RR) Enzyme as an Anti-Cancer Target

Since Ribonucleotide Reductase (RR) is the rate-limiting or bottle-neck enzyme in synthesis of DNA and thus in cell growth, it is perhaps the most important target in anti-cancer strategy. There are many published articles on this subject. Here is one example, written by Dr. Yun Yen (and others) whom I met at City of Hope Medical Center:

Ribonucleotide reductase inhibitors and future drug design